long-term methadone intake and genotoxicity in addicted patients
نویسندگان
چکیده
conclusions genome instability in addicted patients was demonstrated in this study. controversially, considering incoherent results of previous studies and our data, more studies in longer duration of methadone use are needed to elucidate the consequence. results the mutagenicity index in addicted group was robustly higher than healthy volunteers. fortunately, this significant difference was lower than positive control. background it is well known that contact with some physical, chemical or biological compounds can increase the incidence of mutation. among these compounds, are pharmaceuticals that meet long duration of use and potentially could be misused and taken more than the ordered dosage. objectives the aim of this study was to evaluate mutagenic effect of methadone in addicted patients referred to imam khomeini hospital in ahvaz by single cell gel electrophoresis technic or comet assay. patients and methods in this study, 90 subjects were divided into dichromate treated group, no treated healthy volunteers group and test group. each group included 30 subjects. screening was performed according to questionnaire and qualified subjects were entered the study. blood samples were collected and lymphocytes were isolated, mixed with low melting point agarose for slide preparation according to standard method. slides were analyzed using fluorescence microscope and comet patterns were assessed.
منابع مشابه
Long-Term Methadone Intake and Genotoxicity in Addicted Patients
BACKGROUND It is well known that contact with some physical, chemical or biological compounds can increase the incidence of mutation. Among these compounds, are pharmaceuticals that meet long duration of use and potentially could be misused and taken more than the ordered dosage. OBJECTIVES The aim of this study was to evaluate mutagenic effect of methadone in addicted patients referred to Im...
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By attempting to quit and seeking help from others, you've already taken a remarkable first step in the direction of change. For those who may be unfamiliar, methadone is a synthetic opioid drug that is commonly used to treat narcotic or opiate addiction (such as heroin). Regardless of whether you started taking methadone to treat a drug addiction, pain, or for recreational purposes, it can be ...
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By attempting to quit and seeking help from others, you've already taken a remarkable first step in the direction of change. For those who may be unfamiliar, methadone is a synthetic opioid drug that is commonly used to treat narcotic or opiate addiction (such as heroin). Regardless of whether you started taking methadone to treat a drug addiction, pain, or for recreational purposes, it can be ...
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عنوان ژورنال:
jundishapur journal of natural pharmaceutical productsجلد ۱۰، شماره ۱، صفحات ۰-۰
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